We investigate the multipartite entanglement in arbitrary dimensional systems, and separability criteria for nonseparability in n-partite quantum states are derived. Examples such as the generalized noisy-W state and the GHZ basis states mixed with white noise are provided to show that our criteria are independent of and stronger than previously reported ones. Our criteria can also be expressed by the elements of the density matrix, which allows a simple and practical evaluation and computation. The experimental implementation of our criteria is also discussed.