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Wiley, International Journal of Experimental Pathology, 3(92), p. 202-210, 2010

DOI: 10.1111/j.1365-2613.2010.00730.x

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Oxidative stress in obstructive nephropathy

Journal article published in 2011 by Amélie Dendooven, David A. Ishola, Tri Q. Nguyen ORCID, Dionne M. Van der Giezen, Robbert Jan Kok, Roel Goldschmeding, Jaap A. Joles
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.