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American Association for the Advancement of Science, Science, 5770(312), p. 55-55, 2006

DOI: 10.1126/science.1122000

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Comment on ‘PDK1 nucleates T cell receptor-induced signaling complex for NF-B activation’

Journal article published in 2006 by Nikolaus Thuille, Isabelle Heit, Stephen Shaw, Aideen Long, Michael Freeley, Thomas Gruber, Gottfried Baier ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We observe that protein kinase C θ (PKCθ) is phosphorylated on the activation loop at threonine 538 (Thr-538) before T cell activation. Our results are inconsistent with the conclusions of Lee et al . (Reports, 1 April 2005, p. 114) that the Thr-538 phosphorylation of PKCθ is regulated by T cell receptor activation. Other mechanisms, such as autophosphorylation of Thr-219, might orchestrate the cellular function of PKCθ in T cells.