<i>Aim:</i> To describe clinical features, treatment modalities and long-term outcome of patients with overt metastatic breast cancer in complete remission for more than 5 years. <i>Patients and Methods:</i> A retrospective survey of 12 patients who were referred to a single institution from 1982 to 1995. <i>Results:</i> The majority of the long-term survivors had a good performance status, endocrine-responsive disease and a single metastatic site. Ten patients had received chemotherapy, 8 patients hormone therapy, and 2 patients had been treated with surgery followed by systemic therapies. At a median follow-up of 11.7 years, 10 of the 12 patients were still in complete remission. The median duration of complete remission was 9.2 years (range 5.0–15.7 years). <i>Conclusions:</i> This case series confirms that only a few metastatic breast cancer patients could potentially be cured with multidisciplinary treatments.