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Rockefeller University Press, Journal of General Physiology, 1(125), p. 37-39, 2004

DOI: 10.1085/jgp.200409195

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Hypertonic Stress and Amino Acid Deprivation Both Increase Expression of mRNA for Amino Acid Transport System A

Journal article published in 2004 by Roberta R. Alfieri, Mara A. Bonelli, Pier Giorgio Petronini, Silvia Desenzani, Andrea Cavazzoni ORCID, Angelo F. Borghetti, Kenneth P. Wheeler
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Amino acid transport system A (SNAT2) in Chinese hamster ovary (CHO-K1) cells was stimulated when the cells were depleted of amino acids or subjected to hypertonic stress. Each of these stresses also caused increases in the abundance of SNAT2 mRNA in these cells. Similar results were obtained with Madin-Darby canine kidney (MDCK) cells, porcine pulmonary artery endothelial cells and human WI-38 fibroblasts. We conclude that the cellular signal transduction pathways for hypertonic stress and amino acid starvation must converge at or before transcription of the message for SNAT2.