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Ferrata Storti Foundation, Haematologica, 9(92), p. 1254-1257

DOI: 10.3324/haematol.11279

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Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: Incidence, risk factors and outcome

Journal article published in 2007 by Marie Robin, Stéphanie Marque-Juillet, R. P. de Latour, Catherine Scieux, Regis Peffault De Latour, Christèle Ferry, Vanderson Rocha, Jean-Michel Molina, Anne Bergeron ORCID, Agnès Devergie, Eliane Gluckman, Patricia Ribaud, Gérard Socié
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We analyzed the factors and outcome of patients with disseminated adenovirus infection (dAdV) after allogeneic hematopoeitic stem cell transplantation (HSCT). Thirty patients with dAdV were identified among 620 allogeneic HSCT recipients. Primary diseases were leukemia (n=17), Fanconi anemia (n=12) or others (n=1). Source of stem cells was unrelated in 28 and related in 2 patients. The graft consisted of peripheral blood (n=3), bone marrow (n=12) and unrelated cord-blood (UCB, n=15). Risk factors for dAdV in unrelated HSCT recipients were previous Fanconi disease (p=0.03) and GVHD (p=0.02) in children, and cord blood source of stem cells (p=0.029) and GVHD (0.024) in adults.