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American Association for the Advancement of Science, Science, 5850(318), p. 652-655, 2007

DOI: 10.1126/science.1147248

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A Linear Pentapeptide Is a Quorum-Sensing Factor Required for mazEF-Mediated Cell Death in Escherichia coli

Journal article published in 2007 by Ilana Kolodkin-Gal, Ronen Hazan ORCID, Ariel Gaathon, Shmuel Carmeli, Hanna Engelberg-Kulka
This paper is available in a repository.
This paper is available in a repository.

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Abstract

mazEF is a toxin-antitoxin module located on many bacterial chromosomes, including those of pathogens. Here, we report that Escherichia coli mazEF -mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF). Structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn. Each of the five amino acids of EDF is important for its activity.