Institute of Electrical and Electronics Engineers, IEEE Transactions on Circuits and Systems II: Express Briefs, 2(62), p. 164-168, 2015
DOI: 10.1109/tcsii.2014.2386233
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A system for cell-culture real-time monitoring using an oscillation-based approach is proposed. The system transforms a cell culture under test into a suitable “biological” oscillator, without needing complex circuitry for excitation and measurement. The obtained oscillation parameters are directly related to biological test, owed to an empirically extracted cell-electrode electrical model. A discrete prototype is proposed and experimental results with living cell culture are presented, achieving the expected performances.