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Wiley, Advanced Synthesis & Catalysis, 4-5(348), p. 471-475, 2006

DOI: 10.1002/adsc.200505395

Wiley, Advanced Synthesis & Catalysis, 7-8(348), p. 792-792

DOI: 10.1002/adsc.200690008

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A One‐Pot Enantioselective Chemo‐Enzymatic Synthesis of Amino Acids in Water

Journal article published in 2006 by Chrétien Simons, Ulf Hanefeld, Isabel W. C. E. Arends, Thomas Maschmeyer ORCID, Roger A. Sheldon
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The combination of immobilised Rh-MonoPhos (1-AlTUD-1) and acylase I afforded a chemo-enzymatic, one-pot process for the enantioselective synthesis of amino acids in water, without the need for isolation of intermediates. In addition, the enzymatic hydrolysis increases the enantiopurity of the product from 95% ee to >98% ee. Compatibility studies revealed that for optimum results compartmentalisation of the catalysts is required.