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Wiley, Angewandte Chemie, 41(124), p. 10461-10464

DOI: 10.1002/ange.201204596

Wiley, Angewandte Chemie International Edition, 41(51), p. 10315-10318, 2012

DOI: 10.1002/anie.201204596

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Creation of Pure Nanodrugs and Their Anticancer Properties

Journal article published in 2012 by Hitoshi Kasai, Tatsuya Murakami, Yoshikazu Ikuta, Yoshitaka Koseki, Koichi Baba, Hidetoshi Oikawa, Hachiro Nakanishi, Masahiro Okada, Mitsuru Shoji, Minoru Ueda, Hiroshi Imahori ORCID, Mitsuru Hashida
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Abstract

A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.