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Public Library of Science, PLoS ONE, 3(8), p. e58354, 2013

DOI: 10.1371/journal.pone.0058354

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White Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study

Journal article published in 2013 by Martínez González Má, Miguel Ángel Martínez-González, Julia Wärnberg ORCID, Manuel Ortega-Calvo, Itziar Salaverría, Lluís Serra-Majem, Covas Mi, José Vicente Sorli, Study Investigators Predimed, Jordi for the Predimed Study Investigators Salas-Salvadó, M. A. (Miguel Ángel) Martinez-Gonzalez, Nancy Babio, Núria Ibarrola-Jurado, Mònica Bulló, Ramon Estruch and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND: The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS. METHODS: Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n = 4,377) and a prospective assessment (n = 1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components. RESULTS: Of the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95%CI, 2.03-2.99; P-trend