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Beilstein-Institut, Beilstein Journal of Organic Chemistry, (7), p. 179-197, 2011

DOI: 10.3762/bjoc.7.25

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Approaches towards the synthesis of 5-aminopyrazoles

Journal article published in 2011 by Ranjana Aggarwal, Vinod Kumar, Rajiv Kumar, Shiv P. Singh
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The biological and medicinal properties of 5-aminopyrazoles have prompted enormous research aimed at developing synthetic routes to these heterocyles. This review focuses on the biological properties associated with this system. Various synthetic methods developed up to 2010 for these compounds are described, particularly those that involve the reactions of β-ketonitriles, malononi-trile, alkylidenemalononitriles and their derivatives with hydrazines, as well as some novel miscellaneous methods.