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Oxford University Press, Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders, 2(42), p. 406-414, 2015

DOI: 10.1093/schbul/sbv074

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Correspondence of DNA Methylation Between Blood and Brain Tissue and its Application to Schizophrenia Research

Journal article published in 2015 by Esther Walton ORCID, Johanna Hass, Jingyu Liu, Joshua L. Roffman, Fabio Bernardoni, Veit Roessner, Matthias Kirsch, Gabriele Schackert, Vince Calhoun, Stefan Ehrlich ORCID
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This paper is available in a repository.

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Abstract

Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry concerns the extent to which epigenetic signatures measured in more accessible tissues such as blood can serve as a surrogate marker for the brain. Here, we aimed (1) to investigate the blood-brain correspondence of DNA methylation using a within-subject design and (2) to identify changes in DNA methylation of brain-related biological pathways in schizophrenia.