Published in
Elsevier, Biophysical Journal, 2(106), p. 775a-776a, 2014
DOI: 10.1016/j.bpj.2013.11.4254
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Cardiac Myosin Binding Protein-C Phosphorylation and Sarcomere Function
Journal article published in 2014 by
Mohit Kumar 
,
Suresh Govindan,
Sakthivel Sadayappan ,
Pieter P. de Tombe
,
Suresh Govindan,
Sakthivel Sadayappan ,
Pieter P. de Tombe
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Abstract
Cardiac myosin binding protein-C (cMyBP-C) has three phosphorylatable serines at N-terminus (Ser-273, Ser-282, and Ser-302) and phosphorylation states of these serines may alter the thick filament structure and function. Phosphorylation of these serines in cMyBP-C may also alter sarcomere length-dependent modulation of contractile force development (LDA), which would be expected to modulate the Frank-Starling Law of the Heart.