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Oxford University Press, Open Forum Infectious Diseases, 2(2), 2015

DOI: 10.1093/ofid/ofv044

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Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children

Journal article published in 2015 by Regis W. Tiendrebeogo, Bright Adu, Susheel K. Singh, Morten H. Dziegiel, Issa Nébié, Sodiomon B. Sirima ORCID, Michael Christiansen, Daniel Dodoo, Michael Theisen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.