Abrupt changes in the African monsoon can have pronounced socioeconomic impacts on many West African countries. Evidence for both prolonged humid periods and monsoon failures have been identified throughout the late Pleistocene and early Holocene epochs 1,2. In particular, drought conditions in West Africa have occurred during periods of reduced North Atlantic thermohaline circulation, such as the Younger Dryas cold event 1. Here, we use an ocean–atmosphere general circulation model to examine the link between oceanographic changes in the North Atlantic Ocean and changes in the strength of the African monsoon. Our simulations show that when North Atlantic thermohaline circulation is substantially weakened, the flow of the subsurface North Brazil Current reverses. This leads to decreased upper tropical ocean stratification and warmer sea surface temperatures in the equatorial South Atlantic Ocean