The aim of this study is to assess aerobic, anaerobic and performance indexes changes after a short period of coenzyme Q 10 Supplementation in soccer players. 16 soccer players (Weight 57.1±20.72, height 171.4±4.92, and age 22.30±1.41) randomized and divided into two groups. Where supplement group (N=10) consumed CoQ 10 supplement (300 mg/day) and placebo group (n=6) consumed placebo. Both of them practiced for 4 weeks and each one 90 minutes. After that, supplement group started to consume CoQ 10 in amount of 300 mg/day for one month. Findings has been showed that 4-week supplement consumption caused significant changes in VO 2max and performance in soccer players, while this intervention did not result in significant effect in body composition, maximum running speed, peak anaerobic power and fatigue index. The major findings of the present study were that 4-week of CoQ 10 supplement consumption in college soccer players led to increase aerobic power and performance in high intensity aerobic interval test. From the other point of view, these variations were not significant in placebo group. We can conclude that although increase in maximum running speed (vVO 2max) was not significant, four weeks of CoQ 10 supplement consumption may increase in maximal oxygen consumption and performance in college soccer players. Finally, in this case consumption of this supplement could improve player's performance in competition conditions. [Nima Gharahdaghi, Fatemeh Shabkhiz, Ehsan Azarboo, Abbas Keyhanian. The Effects of Daily Coenzyme Q 10 Supplementation on VO 2max , vVO 2max and Intermittent Exercise Performance in Soccer Players. Life Sci J 2013;10(8s):22-28] (ISSN:1097-8135). http://www.lifesciencesite.com. 3