Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Genetics, 4(40), p. 395-402, 2008

DOI: 10.1038/ng.102

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Newly identified genetic risk variants for celiac disease related to the immune response

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

PUBLISHED ; * Joint Senior Authors ; We acknowledge funding from Coeliac UK (to DAvH); the Coeliac Disease Consortium (an innovative cluster approved by the Netherlands Genomics Initiative and partly funded by the Dutch Government, grant BSIK03009 to CW); the European Union (STREP 036383); the Netherlands Organization for Scientific Research (VICI grant 918.66.620 to CW); the Science Foundation Ireland; the Irish Health Research Board; Hitachi Europe Ltd.; and the Wellcome Trust (GR068094MA Clinician Scientist Fellowship to DAvH; New Blood Fellowship to RMcM; support for the work of RMcG and PD). We thank the Barts and The London Genome Centre for genotyping support; J Swift, P. Kumar, D.P. Jewell, S.P.L. Travis, K. Moriarty for collection of UKGWAS and additional samples. We acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by the UK Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02. We thank A. Monsuur for patient recruitment, G. Meijer and J. Meijer for histology review, K. Duran for DNA extraction, H. van Someren and F. Mulder for clinical database management, M. Plateel and the Genotyping facilities at UMCG and UMC Utrecht for technical assistance (the Netherlands). We thank M. Abuzakouk, R. McLoughlin, K. Brophy, C. Feighery, J. McPartlin for sample collection. Irish Control DNA was supplied by Irish Blood Transfusion Service/Trinity College Dublin Biobank. We thank the Wellcome Trust Centre for Human Genetics, University of Oxford for provision of computing facilities and G. McVean for recombination rate data. We thank all celiac and control individuals for participating in this study.