Published in
Elsevier, Brain Research, 1(992), p. 137-141, 2003
DOI: 10.1016/s0006-8993(03)03456-5
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Selective alteration of DNA fragmentation and caspase activity in the spinal cord of aged rats and effect of dietary restriction
Journal article published in 2003 by
Barbara Monti 
,
Antonio Contestabile
,
Antonio Contestabile
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Abstract
Age-related alterations in CNS may preferentially affect spinal cord. We report here that in spinal cord of aged (30-month-old) rats, a significant increase of DNA fragmentation accompanied by an increased activity of caspase-1, but not of caspase-3, can be measured. The increase in caspase-1 activation, but not the increased level of DNA fragmentation, was substantially reverted by long-lasting dietary restriction.