Dissemin is shutting down on January 1st, 2025

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Elsevier, International Journal of Antimicrobial Agents, 1(43), p. 82-85

DOI: 10.1016/j.ijantimicag.2013.08.021

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IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages

Journal article published in 2014 by Valnês S. Rodrigues-Junior, André A. dos Santos Junior, Anne D. Villela, Juan M. Belardinelli ORCID, Héctor R. Morbidoni, Luiz A. Basso, Maria M. Campos, Diógenes S. Santos
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

In this work, the antitubercular activity of a pentacyano(isoniazid)ferrate(II) compound (IQG-607) was investigated using a macrophage model of Mycobacterium tuberculosis infection. Importantly, treatment of M.-tuberculosis-infected macrophages with IQG-607 significantly diminished the number of CFU compared with the untreated control group. The antitubercular activity of IQG-607 was similar to that observed for the positive control drugs isoniazid and rifampicin. Nevertheless, higher concentrations of IQG-607 produced a significantly greater reduction in bacterial load compared with the same concentrations of isoniazid. Analysis of the mechanism of action of IQG-607 revealed that the biosynthesis of mycolic acids was blocked. The promising activity of IQG-607 in infected macrophages and the experimental determination of its mechanism of action may help in further studies aimed at the development of a new antimycobacterial agent.