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Public Library of Science, PLoS Computational Biology, 9(7), p. e1002200, 2011

DOI: 10.1371/journal.pcbi.1002200

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Why Don't CD8+ T Cells Reduce the Lifespan of SIV-Infected Cells In Vivo?

Journal article published in 2011 by Marjet Elemans ORCID, Nafisa-Katrin Seich al Basatena, Nafisa-Katrin Seich al Basatena, Nichole R. Klatt, Christos Gkekas, Guido Silvestri, Becca Asquith ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.