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American Society for Microbiology, Journal of Virology, 1(86), p. 621-624, 2012

DOI: 10.1128/jvi.05718-11

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Viral Expression Directs the Fate of B Cells in Bovine Leukemia Virus-Infected Sheep

Journal article published in 2011 by Arnaud Florins, Alix de Brogniez, Marjet Elemans ORCID, Amel-Baya Bouzar, Carole François, Michal Reichert, Becca Asquith ORCID, Luc Willems
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The host immune response is believed to tightly control viral replication of deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV). However, this assumption has not been definitely proven in vivo . In order to further evaluate the importance of the immune response in the BLV model, we studied the fate of cells in which viral expression was transiently induced. Using a dual fluorochrome labeling approach, we showed that ex vivo induction of viral expression induces higher death rates of B cells in vivo . Furthermore, cyclosporine treatment of these animals indicated that an efficient immune response is required to control virus-expressing cells.