Muscle adaptations can be induced by high-resistance exercise. Despite being potentially more suitable for older adults, low-resistance exercise protocols have been less investigated. We compared the effects of high- and low-resistance training on muscle volume, muscle strength, and force-velocity characteristics. Fifty-six older adults were randomly assigned to 12 weeks of leg press and leg extension training at either HIGH (2 x 10-15 repetitions at 80% of one repetition maximum (1RM)), LOW (1 x 80-100 repetitions at 20% of 1RM), or LOW+ (1 x 60 repetitions at 20% of 1RM, followed by 1 x 10-20 repetitions at 40% 1RM). All protocols ended with muscle failure. Leg press and leg extension 1RM were measured at baseline and post intervention, and before the first training session in week 5 and 9. At baseline and post intervention, muscle volume (MV) was measured by CT-scan. A Biodex dynamometer evaluated knee extensor static peak torque in different knee angles (PTstat90°, PTstat120°, PTstat150°), dynamic peak torque at different speeds (PTdyn60°s(-1), PTdyn180°s(-1), PTdyn240°s(-1)), and speed of movement at 20% (S20), 40% (S40), and 60% (S60) of PTstat90°. HIGH and LOW+ resulted in greater improvements in 1RM strength than LOW (p < 0.05). These differences were already apparent after week 5. Similar gains were found between groups in MV, PTstat, PTdyn60°s(-1), and PTdyn180°s(-1). No changes were reported in speed of movement. HIGH tended to improve PTdyn240°s(-1) more than LOW or LOW+ (p = 0.064). In conclusion, high- and low- resistance exercise ending with muscle failure may be similarly effective for hypertrophy. High-resistance training led to a higher increase in 1RM strength than low-resistance training (20% of 1RM), but this difference disappeared when using a mixed low-resistance protocol in which the resistance was intensified within a single exercise set (40% of 1RM). Our findings support the need for more research on low-resistance programs in older age, in particular long-term training studies and studies focusing on residual effects after training cessation.