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BioMed Central, Genome Biology, 12(12), p. 413

DOI: 10.1186/gb-2011-12-12-413

BioMed Central, Genome Biology, 10(12), p. R101

DOI: 10.1186/gb-2011-12-10-r101

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SpeCond: a method to detect condition-specific gene expression

Journal article published in 2011 by Florence Mg G. Cavalli, Richard Bourgon ORCID, Wolfgang Huber, Juan M. Vaquerizas ORCID, Nicholas M. Luscombe
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Transcriptomic studies routinely measure expression levels across numerous conditions. These datasets allow identification of genes that are specifically expressed in a small number of conditions. However, there are currently no statistically robust methods for identifying such genes. Here we present SpeCond, a method to detect condition-specific genes that outperforms alternative approaches. We apply the method to a dataset of 32 human tissues to determine 2,673 specifically expressed genes. An implementation of SpeCond is freely available as a Bioconductor package at http://www.bioconductor.org/packages/release/bioc/html/SpeCond.html .