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Cambridge University Press, British Journal of Psychiatry, 4(203), p. 310-311, 2013

DOI: 10.1192/bjp.bp.112.122838

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Pattern recognition analysis of anterior cingulate cortex blood flow to classify depression polarity†

Journal article published in 2013 by J. R. C. Almeida, Almeida Jr, J. Mourao-Miranda, Hj J. Aizenstein, Aizenstein Hj, A. Versace, Kozel Fa, Fa A. Kozel, H. Lu, A. Marquand ORCID, LaBarbara Ej, Ej J. LaBarbara, M. Brammer, M. Trivedi, Kupfer Dj and other authors.
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This paper is available in a repository.

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Abstract

SummaryDifferentiating bipolar from recurrent unipolar depression is a major clinical challenge. In 18 healthy females and 36 females in a depressive episode – 18 with bipolar disorder type I, 18 with recurrent unipolar depression – we applied pattern recognition analysis using subdivisions of anterior cingulate cortex (ACC) blood flow at rest, measured with arterial spin labelling. Subgenual ACC blood flow classified unipolar v. bipolar depression with 81% accuracy (83% sensitivity, 78% specificity).