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Elsevier, Neurobiology of Disease, 1(48), p. 124-131, 2012

DOI: 10.1016/j.nbd.2012.06.016

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Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis

Journal article published in 2012 by Peters Om, Shelkovnikova Ta, Buchman Vl, Owen Morgan Peters, Steven Millership ORCID, Tatyana A. Shelkovnikova, Ileana Soto ORCID, Lora Keeling, Anthony Hann, Nicholas Marsh-Armstrong, Vladimir L. Buchman ORCID, Natalia Ninkina
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Amyotrophic lateral sclerosis (ALS) is characterised by substantial loss of both upper and lower motor neuron function, with sensory and cognitive systems less affected. Though heritable forms of the disease have been described, the vast majority of cases are sporadic with poorly defined underlying pathogenic mechanisms. Here we demonstrate that the neurological pathology induced in transgenic mice by overexpression of γ-synuclein, a protein not previously associated with ALS, recapitulates key features of the disease, namely selective damage and loss of discrete populations of upper and lower motor neurons and their axons, contrasted by limited effects upon the sensory system.