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Instituto Oswaldo Cruz, Ministério da Saúde, Memórias do Instituto Oswaldo Cruz., 8(110), p. 981-988

DOI: 10.1590/0074-02760150163

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Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

Journal article published in 2015 by Nicolli Bellotti de Souza, Nicolli Bellotti de Souza, Alane Cabral de Oliveira, Anna Caroline Campos Aguiar, Alane Cabral de Oliveira, Siden Top, Pascal Pigeon ORCID, Gérard Jaouen, Marilia Oliveira Fonseca Goulart, Antoniana Ursine Krettli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile.