Published in
Elsevier, Tetrahedron Letters, 52(50), p. 7318-7321
DOI: 10.1016/j.tetlet.2009.10.057
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Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN
Journal article published in 2009 by
Antonio Massa,
Arrigo Scettri,
Rosanna Filosa 
,
Laura Capozzolo
,
Laura Capozzolo
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Abstract
The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to β-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiCl4 and i-Pr2EtN in attaining the final products are also discussed.