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Cold Spring Harbor Perspectives in Biology, 9(2), p. a003004-a003004

DOI: 10.1101/cshperspect.a003004

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Antigen Receptor Signaling to NF- B via CARMA1, BCL10, and MALT1

Journal article published in 2010 by M. Thome ORCID, J. E. Charton, C. Pelzer, S. Hailfinger
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The signaling pathway controlling antigen receptor-induced regulation of the transcription factor NF-kappaB plays a key role in lymphocyte activation and development and the generation of lymphomas. Work of the past decade has led to dramatic progress in the identification and characterization of new players in the pathway. Moreover, novel enzymatic activities relevant for this pathway have been discovered, which represent interesting drug targets for immuno-suppression or lymphoma treatment. Here, we summarize these findings and give an outlook on interesting open issues that need to be addressed in the future.