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Elsevier, Cell, 7(107), p. 819-822, 2001

DOI: 10.1016/s0092-8674(01)00620-1

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Multisite Phosphorylation and the Countdown to S Phase

Journal article published in 2001 by Raymond J. Deshaies ORCID, James E. Ferrell
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Remarkably, SCF(Cdc4) ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates. This numerical wizardry suggests how analog inputs can be rectified to digital outputs. Unraveling the counting mechanism promises to generate new insights into the architecture of protein nanoprocessors.