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Wiley, Angewandte Chemie International Edition, 25(49), p. 4228-4232, 2010

DOI: 10.1002/anie.200905936

Wiley, Angewandte Chemie, 25(122), p. 4324-4328, 2010

DOI: 10.1002/ange.200905936

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Striking Inflammation from Both Sides: Manganese(II) Pentaazamacrocyclic SOD Mimics Act Also as Nitric Oxide Dismutases: A Single-Cell Study

Journal article published in 2010 by Miloš R. Filipović, Alaric C. W. Koh, Stéphane Arbault ORCID, Vesna Niketić, Andrea Debus, Ulrike Schleicher, Christian Bogdan, Manon Guille, Frédéric Lemaître, Christian Amatore ORCID, Ivana Ivanović-Burmazović
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Abstract

[Figure Presented] macrophage Removing cytotoxics: A MnII- pentaazamacrocycle removes NO; Cy2- and their ONOO - product as shown by real-time amperometry at single cells (see picture). This is the first compound able to completely abolish the cytotoxic effects of reactive oxygen (ROS) and reactive nitrogen species (RNS) in inflammation.