Among four white-rot basidiomycetes tested, monocultures of Irpex lacteus and Pycnoporus coccineus accumulated the highest endoglucanase (53.2 and 61.5 U ml-1), FPA (3.9 and 5.1 U ml-1), and xylanase (58.9 and 58.6 U ml-1) activities in submerged fermentation of crystalline cellulose. Co-cultivation of these two fungi accompanied with their synergism in enzyme production and provided the highest yields of cellulase and xylanase. By contrast, mixed cultivation of Trametes versicolor with P. coccineus 310 appeared to be unfavourable for cellulases and xylanase production. In co-cultivation of I. lacteus and P. coccineus it was established that the hydrolases yield depends on the growth substrates, nitrogen source, and their concentrations. The medium containing 2% avicel and 4% mandarin peels along with peptone at concentration of 40 mM provided an abundant growth of fungi and accumulation of 127 U ml-1 CMCase, 6.6 U ml-1 FPA, and 136.2 U ml-1 xylanase activity.