The challenge of disease and death caused by infectious diseases is strikingly apparent in both developed and developing nations around the world, with developing countries being the most affected. As infectious diseases evolve and pathogens develop resistance to existing pharmaceuticals, the search for new novel leads, possibly with different modes of action, against fungal, bacterial, and viral diseases has intensified in recent years. To most of the African population, the use of medicinal plants to combat these challenges forms an integral component of their culture and hence a prominent characteristic. To this extent, several species have been subjected to different pharmacological screening techniques using different pathological strains. As a result, varied ranges of bioactivities have been reported for a number of species, different plant parts, and even geographical location and season. We present here the best reported antimicrobial activities of "Africa's top 50 medicinal plants.".