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Springer, Pflügers Archiv European Journal of Physiology, 3(458), p. 443-457, 2009

DOI: 10.1007/s00424-008-0633-z

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Atrial arrhythmogenesis in wild-type and Scn5a+/Δ murine hearts modelling LQT3 syndrome

Journal article published in 2009 by Yana Dautova, Yanmin Zhang, Ian Sabir, Andrew A. Grace, Christopher L.-H. Huang
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Long QT(3) (LQT3) syndrome is associated with abnormal repolarisation kinetics, prolonged action potential durations (APD) and QT intervals and may lead to life-threatening ventricular arrhythmias. However, there have been few physiological studies of its effects on atrial electrophysiology. Programmed electrical stimulation and burst pacing induced atrial arrhythmic episodes in 16 out of 16 (16/16) wild-type (WT) and 7/16 genetically modified Scn5a+/Δ (KPQ) Langendorff-perfused murine hearts modelling LQT3 (P