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American Society for Microbiology, Clinical and Vaccine Immunology, 6(16), p. 956-958, 2009

DOI: 10.1128/cvi.00023-09

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Cellular and Humoral Responses toLeishmania majorVirulence Factors in Healed Cutaneous Leishmaniasis and Mediterranean Visceral Leishmaniasis Patients

Journal article published in 2009 by Inès Lakhal-Naouar ORCID, Thouraya Boussoffara, Amel Meddeb-Garnaoui, Yosser Ben Achour-Chenik, Hechmi Louzir, Mehdi Chenik
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Cellular and humoral immune responses of healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients were evaluated against results for Leishmania major virulence proteins L. major protein disulfide isomerase (LmPDI) and mitogen-activated protein kinase kinase (MAPKK). Only MAPKK induces significant peripheral blood mononuclear cell proliferation with gamma interferon production as well as antibody responses. Thus, MAPKK may be of interest in Leishmania vaccination and serodiagnosis.