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BioMed Central, Genome Biology, 3(10), p. R28

DOI: 10.1186/gb-2009-10-3-r28

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Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes

Journal article published in 2009 by Gabi Kastenmüller, Maria Elisabeth Schenk, Johann Gasteiger, Hans-Werner Mewes ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Identifying the biochemical basis of microbial phenotypes is a main objective of comparative genomics. Here we present a novel method using multivariate machine learning techniques for comparing automatically derived metabolic reconstructions of sequenced genomes on a large scale. Applying our method to 266 genomes directly led to testable hypotheses such as the link between the potential of microorganisms to cause periodontal disease and their ability to degrade histidine, a link also supported by clinical studies.