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Springer Nature [academic journals on nature.com], Oncogene, 11(29), p. 1580-1587, 2009

DOI: 10.1038/onc.2009.445

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Regression of murine lung tumors by the let-7 microRNA

Journal article published in 2009 by Phong Trang, Pedro P. Medina, Jason F. Wiggins, Lynnsie Ruffino, Kevin Kelnar, Michael Omotola, Robert Homer ORCID, David Brown, Andreas G. Bader, Joanne B. Weidhaas, Frank J. Slack ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small-cell lung cancer (NSCLC) significantly reduces the tumor burden. These results demonstrate the therapeutic potential of let-7 in NSCLC and point to miRNA replacement therapy as a promising approach in cancer treatment.