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SAGE Publications, Journal of Cerebral Blood Flow and Metabolism, 1(31), p. 41-46, 2010

DOI: 10.1038/jcbfm.2010.186

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External globus pallidus stimulation modulates brain connectivity in Huntington's disease

Journal article published in 2010 by Noémie Ligot, Pierre Krystkowiak, Clémence Simonin, Serge Goldman, Philippe Peigneux, John Van Naemen, Michel Monclus, Simon Frédéric Lacroix, David Devos ORCID, Kathy Dujardin, Christine Delmaire, Eric Bardinet, Arnaud Delval ORCID, Marie Delliaux, Luc Defebvre and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model. ; Journal Article ; Research Support, Non-U.S. Gov't ; info:eu-repo/semantics/published