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Nature Research, Nature Medicine, 1(15), p. 31-33, 2009

DOI: 10.1038/nm.1902

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Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy

Journal article published in 2009 by Magdalena Sarasin-Filipowicz, Jacek Krol, Ilona Markiewicz, Markus H. Heim ORCID, Witold Filipowicz
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes. These data have implications for the prospect of targeting miRNAs for CHC therapy.