Demineralized bone matrix(DBM) might be an alternative graft material functioning as a bone void filler with osteoconductive and osteoinductive properties. But not all clinical studies have reported uniformly favorable results, because most commercial tissue banks do not generally evaluate the degree of bone forming potential of their DBM prior to distribution. The effectiveness of DBM might differ depending on the age and gender of the donor, the residual mineral, the particle size, or the preparation method. What is worse, Allogeneic DBM has shortcomings related to procuring, processing and characterizing bone from a human donor pool. Xenografting is increasingly being developed as a response to the shortage of human tissues. However, antigenic components of bone material are blamed for the reduction of the osteoinductive properties of bone and bone-derived implants. So, xenogeneic bone will be an unlimited supply of available material if it can be processed to render it safe for transplantation to the human host. Fibrin gels, mainly composed of fibrinogen and thrombin, mimic the final stage of blood clotting. Thanks to their hemostatic, mitogenic and angiogenic properties, fibrin gels are widely used in surgery. Fibrin gels are usually sprayed over the wound in order to prevent blood loss. They are well known for their wound healing and tissue regeneration properties, but their use as a bone graft material has been infrequent. The purpose of this study is to determine whether a combination of fibrin gel and xenogeneic DBM would provide three-dimensional tem- plates for bone growth resulting in new bone formation at heterotopic sites in the rat with plasticity.