Published in
Instituto Oswaldo Cruz, Ministério da Saúde, Memórias do Instituto Oswaldo Cruz., 1(110), p. 86-94, 2015
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Tools
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease
,
Jaquelline Carla Valamiel de Oliveira Silva,
Araújo,Márcio Sobreira Silva,
Girley Francisco Machado de Assis,
Martins,Helen Rodrigues,
Jaquelline Carla Valamiel de Oliveira-Silva,
Maykon Tavares Oliveira,
Girley Francisco Machado-De-Assis,
Nı́via Carolina Noguieira Paiva,
Oliveira-Silva,Jaquelline Carla Valamiel De,
Paiva,Nívia Carolina Noguieira,
Márcio Sobreira Silva Araújo
and other authors.
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Abstract
Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/eight strains. BZ offered some benefit, even in not cured animals, what suggest that BZ use may be recommended at least for recent chronic infection of the studied region.