A. Garcia-Saenz et al. ; In this study we analyzed the space–time variation of the risk of bovine tuberculosis (bTB) in cattle between 2006 and 2011. The results indicated that at country level, there were no significant temporal changes between years, but, at county level bTB evolution was more heterogeneous. In some counties, between some years, the prevalence and the incidence of the disease was higher as compared to the global rate in the rest of the counties of Spain. The analysis of potential risk factors indicated that both, a large number of movements from counties with high incidence (>1%), and presence of bullfighting cattle herds increased bTB risk. Red deer abundance, number of goats and number of mixed cattle-goat farms were not significantly associated with the prevalence/incidence of bTB. ; This research was supported by a Grant from the Ministerio de Ciencia e Innovación of Spain (AGL-2010-21098). PhD studies of Garcia-Saenz A, are funded by a FPI Grant from Ministerio de Ciencia e Innovación of Spain (BES-2011-043628) and PhD studies of Guta S., are funded by Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Acevedo P., was supported by a Beatriu de Pinós fellowship funded by ‘Comissionat per a Universitats i Recerca del Departament d’Innovació, Universitats i Empresa’ of the Generalitat de Catalunya, and the COFUND Programme – Marie Curie Actions under 7th Framework Programme of the European Community. He is currently funded from the SFRH/BPD/90320/2012 post-doctoral Grant by Portuguese Fundação para a Ciência e a Tecnologia (FCT) and European Social Fund. ; Peer Reviewed