Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Genetics, 2(27), p. 153-154, 2001

DOI: 10.1038/84769

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Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture

Journal article published in 2001 by Young Le, Lorraine E. Young, Kenneth Fernandes, Tom G. McEvoy, McEvoy Tg, Simon C. Butterwith, Butterwith Sc, Gutierrez Cg, Carlos G. Gutierrez, Catherine Carolan, Peter J. Broadbent, Broadbent Pj, Robinson Jj, John J. Robinson, Ian Wilmut and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.