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Cell Press, American Journal of Human Genetics, 3(93), p. 545-554, 2013

DOI: 10.1016/j.ajhg.2013.07.010

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Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

Journal article published in 2013 by Nora Franceschini, Zhaogong Zhang, Yun Ju Sung, Ervin Fox, Todd L. Edwards, Andrew D. Johnson, J. Hunter Young, Ken Rice, Qing Duan, Michael A. Nalls, Fang Chen, Yun Li, Hua Tang, Yun Ju Sung, Myriam Fornage and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings have failed to replicate to date. We report on a large AA BP GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts and subsequent replication in additional samples of AA (n = 10,386), European ancestry (EA) (n = 69,395), and East Asian ancestry (n = 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p