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Springer, Supportive Care in Cancer, 1(24), p. 401-408, 2015

DOI: 10.1007/s00520-015-2792-8

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Hope, optimism and survival in a randomised trial of chemotherapy for metastatic colorectal cancer

Journal article published in 2015 by Penelope E. Schofield, M. R. Stockler, D. Zannino, N. C. Tebbutt, T. J. Price, R. J. Simes, N. Wong, N. Pavlakis, D. Ransom, E. Moylan, C. Underhill ORCID, D. Wyld, I. Burns, R. Ward, N. Wilcken and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Purpose: Psychological responses to cancer are widely believed to affect survival. We investigated associations between hope, optimism, anxiety, depression, health utility and survival in patients starting first-line chemotherapy for metastatic colorectal cancer. Methods: Four hundred twenty-nine subjects with metastatic colorectal cancer in a randomised controlled trial of chemotherapy completed baseline questionnaires assessing the following: hopefulness, optimism, anxiety and depression and health utility. Hazard ratios (HRs) and P values were calculated with Cox models for overall survival (OS) and progression-free survival (PFS) in univariable and multivariable analyses. Results: Median follow-up was 31 months. Univariable analyses showed that OS was associated negatively with depression (HR 2.04, P