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American Association for the Advancement of Science, Science, 5824(316), p. 608-611, 2007

DOI: 10.1126/science.1139253

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Requirement of bic/microRNA-155 for Normal Immune Function

Journal article published in 2007 by Antony Rodriguez, Elena Vigorito, Simon Clare, Madhuri V. Warren, Philippe Couttet, Dalya R. Soond, Stijn van Dongen, Russell J. Grocock, Partha P. Das, Eric A. Miska ORCID, David Vetrie, Klaus Okkenhaug, Anton J. Enright ORCID, Gordon Dougan, Martin Turner ORCID and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155 –deficient CD4 + T cells identified a wide spectrum of microRNA-155–regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.