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Nature Research, Nature Reviews Molecular Cell Biology, 1(6), p. 9-20, 2005

DOI: 10.1038/nrm1547

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Function and regulation of Cullin-RING ubiquitin ligases

Journal article published in 2005 by Matthew D. Petroski, Raymond J. Deshaies ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin–RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin–RING ligases, and describe how these enzymes can be characterized by a set of general principles.