Nature Research, Nature Immunology, 11(16), p. 1162-1173, 2015
DOI: 10.1038/ni.3288
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Receptors of the Notch family direct the differentiation of helper T cell subsets, but their influence on regulatory T cell (Treg cell) responses is obscure. We found here that lineage-specific deletion of components of the Notch pathway enhanced Treg cell-mediated suppression of type 1 helper T cell (TH1 cell) responses and protected against their TH1 skewing and apoptosis. In contrast, expression in Treg cells of a gain-of-function transgene encoding the Notch1 intracellular domain resulted in lymphoproliferation, exacerbated TH1 responses and autoimmunity. Cell-intrinsic canonical Notch signaling impaired Treg cell fitness and promoted the acquisition by Treg cells of a TH1 cell-like phenotype, whereas non-canonical Notch signaling dependent on the adaptor Rictor activated the kinase AKT-transcription factor Foxo1 axis and impaired the epigenetic stability of Foxp3. Our findings establish a critical role for Notch signaling in controlling peripheral Treg cell function.