Mounting evidence suggests that fetal exposures may exert long-term effects on the function of the skin and of the immune system. This study aimed at assessing whether maternal complications during pregnancy are associated with an increased risk of eczema during childhood.The associations between hypertension/preeclampsia, febrile infections, or gynecological infections during pregnancy and the occurrence of childhood eczema were studied in a population (n = 3907) of children, aged 3-14 yrs, living in Italy. Their parents filled in a standardized questionnaire about the presence of children's eczema and the events that occurred during pregnancy, birth, and the first year of the child's life.7.7\%, 3.8\%, and 6.1\% of the pregnancies were complicated by hypertension/preeclampsia, febrile infections, and gynecological infections, respectively. The prevalence of eczema was significantly higher in children born to mothers who had experienced febrile (35.5\% vs. 22.0\%; p