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American Society for Microbiology, Journal of Virology, 17(81), p. 9601-9604, 2007

DOI: 10.1128/jvi.00666-07

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Differential Polymerase Activity in Avian and Mammalian Cells Determines Host Range of Influenza Virus

Journal article published in 2007 by G. Gabriel, M. Abram, B. Keiner, R. Wagner, H.-D. Klenk, J. Stech ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT As recently shown, mutations in the polymerase genes causing increased polymerase activity in mammalian cells are responsible for the adaptation of the highly pathogenic avian influenza virus SC35 (H7N7) to mice (G. Gabriel et al., Proc. Natl. Acad. Sci. USA 102:18590-18595, 2005). We have now compared mRNA, cRNA, and viral RNA levels of SC35 and its mouse-adapted variant SC35M in avian and mammalian cells. The increase in levels of transcription and replication of SC35M in mammalian cells was linked to a decrease in avian cells. Thus, the efficiency of the viral polymerase is a determinant of both host specificity and pathogenicity.